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KMID : 0352720160400030203
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Journal of Ginseng Research
2016 Volume.40 No. 3 p.203 ~ p.210
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Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease
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Hong Mee-Gun
Lee Yoon-Hyeong
Kim Seung-woo
Suk Ki-Tae
Bang Chang-Seok
Yoon Jai-Hoon
Baik Gwang-Ho
Kim Dong-Joon
Kim Myong-Jo
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Abstract
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Background: Korean Red Ginseng (KRG) is a well-known natural product with anticarcinogenic and antioxidant effects. We evaluated the antifatigue effect of KRG in patients with nonalcoholic fatty liver disease (NAFLD).
Methods: Eighty patients with NAFLD were prospectively randomized to receive 3 wk of KRG or placebo in addition to counseling on healthy eating and regular exercise. Liver function test, proinflammatory cytokines, adiponectin, antioxidant activity, and fatigue score were measured and compared according to the body mass index between the KRG and placebo groups.
Results: The liver function tests were significantly improved after 3 wk of treatment in both groups. The mean levels (at baseline and after treatment) of tumor necrosis factor-a were 108.0 pg/mL 54.8 pg/mL and 92.7 pg/mL 39.0 pg/mL (p ¼ 0.018) in the KRG group and 123.1 pg/mL 42.1 pg/mL and 127.5 pg/ mL 62.2 pg/mL (p ¼ 0.694) in the placebo group, respectively. There was a significant difference in change of adiponectin levels between the KRG (7,751.2 pg/mL 3,108.1 pg/mL and 8,197.3 pg/ mL 2,714.5 pg/mL) and placebo groups (7,711.6 pg/mL 3,041.3 pg/mL and 7,286.1 pg/mL 5,188.7 pg/ mL, p ¼ 0.027). In patients with overweight, the fatigue score was significantly decreased in the KRG group (35.0 13.2 and 24.5 8.9, p ¼ 0.019).
Conclusion: Our results show that KRG might be effective in reducing proinflammatory cytokine and fatigue in overweight patients with NAFLD, in addition to improvements in adiponectin levels.
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KEYWORD
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adiponectin, chronic hepatitis, fatty liver, Panax ginseng
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